A man may have an elevated PSA for a number of reasons. An elevated PSA is a result of the prostate cells or gland being disrupted in some way. The treatment for having an elevated PSA will depend on what is causing the PSA to rise. Let’s take a look as the most common causes of an elevated PSA: Prostatitis. Prostatitis also means a prostate infection, which causes inflammation of the prostate gland. Prostatitis is the most common prostate condition in men younger than 50. It can usually be treated with antibiotics.